TNF and endothelial dysfunction: ADMA synthesis and degradation are regulated by inflammatory activity and, on the other hand, ADMA contributes to the development of inflammation-related endothelial dysfunction via increase in tumor necrosis factor-alpha (TNF-α) concentrations in human-endothelial-cells, decreased NO production by eNOS inhibition and enhanced oxidative stress by eNOS uncoupling [28,29].