Patients with pSS had significantly elevated plasma ADMA, L-arginine and angiostatin levels (0.39 ± 0.08 vs. 0.36 ± 0.06 μmol/L, p = 0.05; 29.07 ± 6.7 vs. 25.4 ± 5.23 μmol/L, p = 0.01; 152.25 ± 60.99 vs. 120.07 ± 38.77 pg/mL, p = 0.01, respectively) and impaired FMD (7.56 ± 3.08 vs. 10.91 ± 1.02%, p = 0.043) compared with controls (Table 3). This evidence concerns the gene PLG and peeling skin syndrome.