A critical step in AD is believed to be the ability of microglia to attach to soluble Aβ oligomers and fibrils through cell-surface receptors such as α6β1 integrin, CD36, CD14, SCARA1, CD47, and Toll-like receptors, namely TLR2, TLR4, TLR6, and TLR9 [79,104,105]. The gene discussed is CD14; the disease is Alzheimer disease.