WA and its derivatives, at the molecular level, extracted from W. somnifera root, exhibit beneficial effects in AD by blocking Aβ production, inhibiting NF-κB activation, preserving synaptic function, decreasing apoptotic cell death, reversing the reduction in cholinergic markers, and improving antioxidant effects via the migration of Nrf2 to the nucleus. This evidence concerns the gene NFKB1 and Alzheimer disease.