NFE2L2 and Alzheimer disease: WA and its derivatives, at the molecular level, extracted from W. somnifera root, exhibit beneficial effects in AD by blocking Aβ production, inhibiting NF-κB activation, preserving synaptic function, decreasing apoptotic cell death, reversing the reduction in cholinergic markers, and improving antioxidant effects via the migration of Nrf2 to the nucleus.