NFKB1 and Alzheimer disease: Berghe et al. (2012) demonstrated that the TAR DNA-binding protein-43, a pathological hallmark of AD, is alleviated by WA and boosted autophagic marker LC3BII level in the brain, while it suppressed NF-κB-dependent neuro-inflammation in frontotemporal lobar degeneration (FTLD) in a mice model [27].