SIRT1 and colonic neoplasm: While we observed strong anti-apoptotic activity after treatment with resveratrol (Figure 3B), some other studies have reported that resveratrol is capable of inducing significant apoptosis in particular cell types, which may be independent of sirtuin-1 activation, including pancreatic, colon cancer cells, U937, HL-60, and MOLT-4 leukemia cells [49,50].