Yan et al. indicated that the presence of MMP17 (membrane-type 4 MMP, MT4-MMP) is capable of promoting cell invasion under hypoxic conditions and observed that MMP17 promotes ameboid cell movement, invadopodia, and the degradation of the ECM in FaDu cells (a cell line of hypopharynx squamous carcinomas) [155]. The gene discussed is MMP17; the disease is squamous cell carcinoma.