Latent membrane protein 1 (LMP1) is the main oncoprotein of EBV, related to complex and related pathways, such as IKK-α, IKK-β, NF-β, SEK/JNK/c-Jun/AP-1, JAK3/STAT, interferon regulatory factor 7 (IRF7), NFkβ, and p38 mitogen-activated protein kinase (MAPK), which contribute to the positive autoregulation of LMP1 expression and EMT induction through Snail and the reduction in E-cadherin, thereby promoting early metastasis for this tumor [82,83]. The gene discussed is NFKB1; the disease is neoplasm.