CDH1 and carcinoma: Hatakeyama et al. reported a better prognosis in patients with an OPSCC and a low expression of E-cadherin, indicating that the behaviors of OPSCCs are different from those of carcinomas located in other sites of the head and neck region, suggesting that an intratumor estimation of heterogeneity system should be developed for HNSCCs associated with EMT to inform decisions regarding the treatment of these tumors [75].