Studies conducted by Chen et al. on in-cell cultures reported that the expression of DNMT3B was aberrant in these carcinomas, and they found that CDH1 (E-cad) was downregulated, CDH2 (N-cad) and VIM (Vimentin) were upregulated, and the knockdown of DNMT3B was related to restoring E-cadherin by demethylation of the CDH1 5 ́region [96]. This evidence concerns the gene DNMT3B and carcinoma.