St John et al. and St John evaluated the relationship between IL-1β and HNSCC culture cells (Tu686 and Tu212), and they found that IL-1β upregulates COX-2, increases the levels of PGE2, and upregulates Snail, increasing the capability of metastasis and pro-inflammatory mediators. The gene discussed is IL1B; the disease is head and neck squamous cell carcinoma.