TNF and tongue squamous cell carcinoma: Liu et al. evaluated the relationship among TNF-α, NF-κβ, and Slug, and they demonstrated that TNF-α increases the expression of Slug in CAL27 and HN13 (tongue squamous cell carcinoma culture cells) and prevents its ubiquitination by inhibiting its binding to GSK-3β via NFkβ [26] (Figure 1a).