SNAI1 and metastatic malignant neoplasm in the lymph nodes: (Figure 1e) Through studies performed in OSCCs, Wushou et al. observed that the overexpression of Twist, Snail, and Slug according to immunohistochemistry was present in tumors with lymph node metastasis, those in advanced clinical stages (III + IV), and moderately and poorly differentiated histological grades, along with the inhibition of the E-cadherin gene [77].