De Morais et al. indicated that the cytoplasmic overexpression of Twist1 in squamous carcinomas of the lip is significantly related to the loss of E-cadherin expression in the membranes of the tumor cells, and the nuclear expression of Twist1 precipitates the loss of E-cadherin’s functions, leading to invasion (Figure 1d) [39]. The gene discussed is TWIST1; the disease is squamous cell carcinoma.