CCR7 and cancer: Slug can also regulate the C-X-C Motif Chemokine Receptor 4 (CXCR4) and C-C chemokine receptor type 7 (CCR7) proteins, related to chemokines that are overexpressed in several types of cancer, including HNSCCs, and, similarly to Twist, can induce cervical lymph node metastasis [27].