Inflammatory cells, such as neutrophils, promote adhesion and tumor seeding by secreting circulating growth factors; then, platelets can interact with tumor cells and activate several signaling pathways (TNF-⍺, NF-κβ, and TGF-β/Smad) that are related to the promotion of EMT and metastasis [24,25]. Here, TGFB1 is linked to neoplasm.