In a diabetic rat model, lut was revealed to have a protective effect on the diabetic heart against myocardial ischemia/reperfusion injury by upregulating the myocardial eNOS pathway, Nrf2 and the Nrf2-related antioxidative signaling pathway, the enhancement of manganese superoxide dismutase (MnSOD) activity, and inhibition of the mitochondrial permeability transition pore (mPTP) [42,43]. This evidence concerns the gene SOD2 and myocardial ischemia.