For example, miR-4510 and miR-30a reduce the activity of the MAPK/ERK signaling pathway in HCC via directly suppressing RAS and RAF, respectively, while miR-330-5p and miR-487 exert the opposite effect on the activity by targeting Sprouty and SPRED, respectively which are negative regulators of the MAPK/ERK signaling pathway (see above) [56,57,58,59]. This evidence concerns the gene RAF1 and hepatocellular carcinoma.