Moreover, a major quinolone alkaloid compound, evodiamine, extracted from E. rutaecarpa reduced obesity and insulin resistance in obese/diabetic KK-Ay mice via signal [17], suggesting the improvement of glucose tolerance and prevention of the progress of insulin resistance associated with obese/diabetic through inhibition of mTOR-S6K signaling and IRS1 serine phosphorylation in adipocytes for this compound. The gene discussed is IRS1; the disease is Insulin resistance.