Subsequently, several gain- and loss-of-function studies across a range of cell types and organisms confirmed BECLIN1 to be a haploinsufficient tumour suppressor [5,6,7], but also demonstrated BECLIN1 to be important across diverse physiological settings, including in murine embryo development [5,6], dauer development, immunity, and neuronal and cardiac health [8]. Here, BECN1 is linked to neoplasm.