MMP16 and breast cancer: In addition, miR-155 has been shown to promote proliferation and migration of BC cells through downregulation of the suppressor of cytokine signaling 1 (SOCS1) and upregulation of the matrix metallopeptidase 16 (MMP16) [27] and miR-23a has been shown to enhance BC progression by directly activating Forkhead Box M1 (FOXM1) and histidine-rich glycoprotein (HRG) at the RNA level [23].