Furthermore, multivariate Cox regression analysis revealed that EFEMP1 expression was an independent predictor of cancer-related death (p = 0.014; hazard ratio [HR], 2.233; 95% confidence interval [CI], 1.179–4.230) and metastasis occurrence (p =0.005; HR,1.21; 95% CI, 1.204–2.756). The gene discussed is EFEMP1; the disease is cancer.