ERBB2 and neoplasm: To determine the most significant canonical pathways and biological networks of EFEMP1 involved in UC, we used IPA to examine the relationship between these highly significant genes; multiple canonical signaling pathways were enriched, including actin cytoskeleton signaling, tumor microenvironment pathway, mitochondrial dysfunction, ErbB2-ErbB3 signaling and ERK/MAPK signaling.