As an important regulator in the extracellular matrix, including cell-to-cell and cell-to-matrix communication, EFEMP1 has been investigated in carcinogenesis [6,7].The deregulation of EFEMP1 in cancer development is complex [8,9,10,11,12,13,14,15,16,17,18]. This evidence concerns the gene EFEMP1 and cancer.