In low-grade MF, benign cells within early MF skin lesions (e.g., keratinocytes and dermal fibroblasts) express high levels of chemokines such as CXCL9, which preferentially attracts CD8 T-cells and T-helper 1 (Th1) cells that have the capacity to kill autologous malignant T-cells and represent an anti-tumor response in early disease [14,64]. Here, CD8A is linked to neoplasm.