CCNL2 and lung cancer: As highlighted in Figure 2, MF is associated with an increase in CCNB1, CCNB2, and CCNF and a decrease in cyclin CCBNL2. Cyclin B1, encoded by CCNB1, is consistently overexpressed in many malignancies such as breast, esophageal, gastric cancer, and lung cancer [30,31,32,33].