For example, it inhibits islet macrophage infiltration and β-cell death in T1D mice by inactivation of the C-X-C motif chemokine ligand 16 (CXCL16)/ox-LDL pathway or the CXCL16/NF-κB signaling pathway [159,160]. The gene discussed is CXCL16; the disease is type 1 diabetes mellitus.