The same was observed in KK-Ay diabetic mice, where C3G improved hyperglycemia and insulin sensitivity by upregulating the expression of GLUT4 and downregulating the expression of retinol binding protein 4 (RBP4) and inflammatory indices (e.g., MCP-1 and TNF-α) in adipose tissue [120]. This evidence concerns the gene RBP4 and Hyperglycemia.