For the skeletal muscle system, resveratrol treatment restores the expression of the insulin receptor (IR) in the skeletal muscle of diabetic rats, whereas increases the expression of GLUT4 and tether containing a UBX domain for GLUT4 (TUG) in adipose tissue [162], which are beneficial for alleviating the metabolic disorders associated with diabetes to a certain extent. Here, INSR is linked to metabolic disease.