Although only part of the polyphenols (including baicalin, quercetin) in NAFLD and MetS progression in regulating the expression of CYP2E1 and activity [80,88,91], a number of polyphenols (resveratrol and curcumin) interact with CYP2E1 in other diseases (e.g., alcohol-induced liver damage, chemically-induced HCC) [253,254,255]. Here, CYP2E1 is linked to metabolic syndrome.