ACACA and metabolic disease: Guo et al. showed that baicalin administration in high-fat diet (HFD)-fed rats relieved metabolic disorders and hepatic steatosis by enhancing adenosine monophosphate activated protein kinase (AMPK) phosphorylation and downregulating the expression of sterol regulatory element binding transcription factor 1c (SREBP-1c) and its target enzymes acetyl-CoA carboxylase alpha (ACACA) and FASN (fatty acid synthase) [77].