DLX3 and precursor B-cell acute lymphoblastic leukemia: In pediatric B-ALL patients with a MLL-AF4 rearrangement, the DLX3 gene has aberrant CpG methylation, which results in reduced expression of DLX3; in contrast, patients with a TEL-AML1 rearrangement, which has a better prognosis, did not have such methylation [60].