PSEN1 and Alzheimer disease: Investigation of the therapeutic effects of CK1δ-derived peptides was performed using the Alzheimer’s-in-a-dish model published by Kim and colleagues, which is based on hNPCs virally transduced with AD-associated mutant forms of APP695 (Swedish and London mutation) and presenilin 1 (PSEN1) with the deletion of exon 9 (ΔE9) [30].