Multiple studies have reported the relevance of SNPs near or in the TNNI3K loci (rs1514175, rs1514176, rs12142020, rs274609), creating a variant in the TNNI3K or FPGT-TNNI3K transcript, which are positively associated with body mass index, eating behavior, and (child-)obesity [45,48,49,50,51]. This evidence concerns the gene TNNI3K and obesity due to melanocortin 4 receptor deficiency.