Further analysis of pathway and gene-metabolite interactions for genes involved with neurodevelopment and signaling identified CAV1, NTRK2, GNAS, ALDH9A1, and ALDH5A1 as intriguing contenders for future study of oxy’s effects on synaptic structures and signaling, as well as opioid dependence in general. This evidence concerns the gene ALDH5A1 and opiate dependence.