The additional analysis of the expression of TRAIL-death receptors (DR4, DR5) on the surface of CRC cells and subsequent demonstration, that their blocking significantly inhibited L. lactis-derived-hsTRAIL induced apoptosis, confirmed the role of extracellular pathway of apoptosis in elimination of CRC cells by L. lactis(hsTRAIL+) (Figure S4). This evidence concerns the gene TNFRSF10B and colorectal carcinoma.