ESM1 and viral load: Beyond the endocan’s role as a possible clinical biomarker of dengue infection and its biological role in the immunopathogenesis of this viral disease, its further study is very attractive because endocan may take part in systemic inflammation or endothelial cell activation or may have an anti-inflammatory effect by blocking the recruitment, adhesion, and activation of leukocytes, all of which are take on biological roles previously described in the literature.