TERF2 and cancer: While TRF2 overexpression in cancer cells strongly inhibits NK cell recruitment in the tumor microenvironment by the regulation of HSPG synthesis [13], the TLR2 activation of MDSC induced by the overexpression of TRF2 leads to a powerful inhibition of the NK cell immunosurveillance with a strong decrease of NK cells degranulation, IFNgamma production and killing [21].