Interestingly, G-protein coupled receptors, which had previously been detected by our group at high frequency for salivary and thyroid MALT lymphoma, were rare (GPR155, n = 1; GPR 35, n = 1) in H. pylori negative gastric MALT lymphoma, further reinforcing the concept of site-specific mutation profiles as previously suggested [16]. This evidence concerns the gene GPR155 and MALT lymphoma.