The following search terms were used in all four databases: “hemopexin AND (sickle cell disease),” “hemopexin AND (sickle cell anemia),” “haemopexin AND (sickle cell disease),” “(beta-1B-glycoprotein) AND (sickle cell disease),” and “(beta-1B-glycoprotein) AND (sickle cell anemia).” Additionally, abbreviations were used in place of sickle cell disease (SCD) and hemopexin (Hpx) to perform a more comprehensive search. The gene discussed is HPX; the disease is sickle cell disease.