PIK3CD and experimental autoimmune encephalomyelitis: In fact, administration of a dual p110α/p110δ PI3K inhibitor inhibited antigen-specific T-cell and antibody responses in vivo, and suppressed clinical symptoms in a model of collagen-induced arthritis (CIA), as did a dual p110α/DNA-PK inhibitor in experimental autoimmune encephalomyelitis (EAE) [16,18,19].