In a recently published study employing an ischemic acute kidney injury (AKI) mouse model, 6-shogaol (20 mg/kg, i.p.)exhibited protective effects against renal ischemia-reperfusion injury by interfering with the NFκB and heme oxygenase 1 (HO-1) signaling pathways [50]. The gene discussed is HMOX1; the disease is acute kidney injury.