Since EWSR1 rearrangement was mentioned in one myoepithelial carcinoma and one myoepithelioma of soft tissue 2007 and 2008 [125,126]; systematic analyses revealed that approximately 50% of myoepithelial tumors of skin, soft tissue, viscera, and bone harbor a EWSR1 fusion gene with a variety of gene partners, including PBX1, PBX3, ZNF 444, POU5F1, ATF1, and KLF17 [126,127,128,129,130,131,132]. This evidence concerns the gene EWSR1 and myoepithelial tumor.