In addition to the improvement of post-ischemic contractile function and the reduction of infarct size, activation of PPARβ/δ resulted in a concomitant reduction in overall ectopic activity and incidence of ventricular tachycardia demonstrating beneficial effect also on arrhythmogenesis after I/R (Figure 1). The gene discussed is PPARD; the disease is ventricular tachycardia.