PDLIM2 and neoplasm: However, in our study, higher PDLIM2 expression was observed in the process of in vivo metastasis adaptation of RenCa kidney cancer cells, and we found that PDLIM2 is highly related to tumor growth and metastasis in mouse knockout model, The epigenetic genetic repression of PDLIM2 negatively affects growth and expression of kidney cancer and spontaneous tumorigenesis following aging.