Finally, using a logistic regression model, we estimated that the combination of GDF-15 and pGSN achieved the best diagnostic performance to differentiate between the global cohorts of MD patients vs. healthy controls, with an AUC = 0.94, CI95% (0.89; 0.98), even better than the combined use of GDF-15 and FGF-21 (AUC = 0.91, CI95% (0.85; 0.96)). Here, GDF15 is linked to Menkes disease.