A closer examination of the top downregulated genes belonging to this pathway revealed that genes linked to pyruvate dehydrogenase activity (PDHB, DLD, and PDHA1), mitochondrial β-oxidation (ACADS, ETFA, ETFB, ECHS1, PCCA, PCCB, ACAT2, and ACOT8), and mitochondrial fatty acid synthesis (AASDHPPT, ACACA, MCAT, MECR, NDUFAB1, OXSM) were downregulated in AD brains compared to controls. Here, ACOT8 is linked to Alzheimer disease.