The same genes linked to the pyruvate dehydrogenase activity were also found to be downregulated in PD brains compared to controls, as well as other genes linked to lipid metabolism, such as DLD, ALDH1A, IDI1, AUH, HMGCL, RDH11, HMGCS1, SERINC1, ACADM, ACAT2, YWHAH, GSTZ1, NSDHL, HSD17B10, MIF, ELOVL5, CPT1A, ACSL4, HPGD, and IDH1. This evidence concerns the gene ACAT2 and Parkinson disease.