STAT3 and Alzheimer disease: GSEA, carried out using the Hallmark molecular signature database, showed that genes upregulated in neurodegenerative disorders tended to be enriched in immune system-related processes, including the inflammatory response (AD: NES = 2.12, p-adj = 4.46 × 10−8, PD: NES = 1.99, p-adj = 8.68 × 10−7), allograft rejection (AD: NES = 2.09, p-adj = 7.03 × 10−8, PD: NES = 1.44, p-adj = 7.95 × 10−3), and IL6-JAK-STAT3 signaling (AD: NES = 2.19, p-adj = 4.69 × 10−6, PD: NES = 2.09, p-adj = 1.26 × 10−5), among others.