Pathways that were upregulated in AD and downregulated in its ODDCs included myogenesis, KRAS signaling, allograft rejection, and the complement cascade, among others (downregulated in at least three ODDCs), whereas pathways that were downregulated in AD and upregulated in its ODDCs included MYC targets, mTORC1 signaling, cell cycle checkpoints, DNA repair, unfolded protein response, proteasome, and stabilization of p53 (upregulated in all eight of AD’s ODDCs). The gene discussed is MYC; the disease is Alzheimer disease.