STAT3 and Alzheimer disease: Pathways that were upregulated in both AD and its SDDCs were linked to immune function, including cytokine–cytokine receptor interaction, interleukin 4 and interleukin 13 signaling, IL6-JAK-STAT3 signaling, inflammatory response, and allograft rejection, as well as other processes, such as extracellular matrix organization, epithelial–mesenchymal transition, and coagulation.