TRAF6 and metabolic dysfunction-associated steatohepatitis: Notably, both miR-146b and miR-182-5p have been linked with protection against high-fat diet-induced non-alcoholic steatohepatitis in mice: exposure to miR-146b reduces the expression of IL-1 receptor-associated kinase (IRAK1) and tumour necrosis factor (TNF) receptor-associated factor 6 (TRAF6) after exposure to oleic acid, reducing inflammation and lipid accumulation in vitro and in vivo [160].