SIRT1 is known to be strongly implicated in the aging process of diverse organisms, including mammals, based on its ability to integrate multiple signaling and transcriptional pathways, in which SIRT1 participates to regulate cellular senescence, metabolic disorders, autophagy, DNA damage and mitochondrial dysfunction, all of which are hallmarks of aging [90,91,92]. This evidence concerns the gene SIRT1 and metabolic disease.