SIRT1 is known to be strongly implicated in the aging process of diverse organisms, including mammals, based on its ability to integrate multiple signaling and transcriptional pathways, in which SIRT1 participates to regulate cellular senescence, metabolic disorders, autophagy, DNA damage and mitochondrial dysfunction, all of which are hallmarks of aging [90,91,92]. The gene discussed is SIRT1; the disease is Other metabolic disease.