Previous clinical studies from our laboratory have demonstrated that bacterial infection such as chorioamnionitis, reduces the protein expression of OATP2B1 in placenta, to 50% of that seen in the placentas obtained from healthy pregnancies [22], while a 2-fold increase in the expression of OATP2B1 was seen in placentas obtained from pregnancies complicated with pre-eclampsia [21]. This evidence concerns the gene SLCO2B1 and bacterial infectious disease.