At the molecular basis, there is the activity of some enzymes, especially hydrolases such as the angiotensin converting enzyme (ACE), which may cause hypertension and cardiovascular diseases, pancreatic lipase that hydrolyzes about 70% of fat from food products in the human gastrointestinal tract, and amylases that hydrolyze polysaccharides into small molecules. The gene discussed is PNLIP; the disease is hypertensive disorder.