Evolving cancer possess metastatic potential which is a multifactorial and multistep process involving a vigorous interplay between several metastasis-associated genes which evoke changes in various signal transduction pathways, and encode different adhesion molecules, extracellular matrix protein hydrolases, angiogenic factors, etc. Studies demonstrate that AEG-1 is notably relevant with invasion and metastasis of cancers. This evidence concerns the gene MTDH and cancer.