While both MAPKs and GSK3β can phosphorylate multiple sites in tau and are involved in tau phosphorylation in AD and other tauopathies [42], these data suggest that MAPKs, but not GSK3β, were likely involved in mediating the effects of oxidative stress on the initial increase of tau phosphorylation following a single mild blast in our study. The gene discussed is MAPT; the disease is Alzheimer disease.