The transcription of NKG2D ligands, namely, MHC class I polypeptide-related chain proteins A (MICA), MICB, UL16 binding protein 1 (ULBP1), ULBP2, and ULBP3, was analyzed after treating lung cancer cells with five types of HDAC inhibitor for 18 h. This evidence concerns the gene ULBP1 and lung cancer.