Glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide expression in the gut of NOD mice appear unchanged by hyperglycaemia [40], and although combinatory therapies with GLP-1 receptor agonists in individuals with T1D have the potential to enhance β-cell function [41], recent Phase III trials (NCT01836523, NCT02098395) have observed elevations in hypoglycaemia and hyperglycaemia with ketosis [42,43]. This evidence concerns the gene GLP1R and type 1 diabetes mellitus.