In animal models of ovalbumin-induced asthma, AMCase is overexpressed, and administration of anti-AMCase antibody or allosamidin, demethylallosamidin (chitinase inhibitors) or bisdionin F (an AMCase-selective inhibitor) leads to alleviation of asthma symptoms and a decrease in Th-2 inflammation, tissue eosinophilia, and leukocyte accumulation [51,52]. This evidence concerns the gene CHIA and Increased total eosinophil count.