NOS2 and Stroke: In hippocampal tissues, mRNA expression studies at 1 h and 24 h, and strongly elevated (Egr1, Akt1, Kras, Src, Foxo, Srf, Vegfr2, Nos3, Nos1) and decreased (Nos2, Nfkb) gene expression (Mapk1 not activated) also support BPC 157 beneficial effect on brain lesions, given in reperfusion in stroke-rats [30].