Finally, in addition to this particular effect [47], there is a direct effect on vasomotor tone (i.e., BPC 157 counteracts both L-NAME-induced hypertension and L-arginine-induced hypotension, and there is a specific activation of Src-Caveolin-1-endothelial nitric oxide synthase (eNOS) pathway [43]. The gene discussed is NOS3; the disease is hypertensive disorder.