PTGS2 and posterior cortical atrophy: On the other hand, Angelucci et al. (2008) observed that AA is a potent mitogenic factor for PCa cells through the production of both 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) metabolites that were responsible for the regulation of the Bcl-2/Bax ratio and apoptosis induction [155].