IFNG and neoplasm: MS4A4A+ macrophages expressing Dectin-1 recognized specific carbohydrates moieties (N-glycans) expressed on tumor cells, leading to the triggering of the Syk pathway downstream Dectin-1 and thus the production of pro-inflammatory molecules required for the activation of NK cell-mediated cytotoxicity, IFNγ and resistance to metastasis [107] (Figure 2D).