JAK3 and breast cancer: The heatmaps of the 10 HR−/HER2+ breast cancers were homogeneous (Figure 5), while for 9 HR-/HER2− cases, a major cluster with ATM, FGFR1, and WT1 frameshift mutations (n = 6 for ATM1, FGFR1 and n = 5 for WT1, Figure 6) and a minor one with JAK3 splice site mutations were prominent (n = 3, Figure 6).