An initial study by Gitik et al. [33] reported that recombinant anti-CD47 antibodies opsonized the CD47+ myelin debris and accelerated FCγR-mediated phagocytosis by SIRPα+ macrophages, suggesting that CD47 protein expressed by either myelin debris, or intact myelin, could be one of the crucial clues associated with the molecular dynamics of CNS repair during the course of demyelination in several neurodegenerative diseases [33]. This evidence concerns the gene CD47 and neurodegenerative disease.