H19 and autoimmune disease: These experimental results indicate that, in effector cells from different autoimmune disorders with specific target organs, distinctive expression of p53-dependent lncRNA such as lincRNA-p21 in SLE pulmonary cells and H19 in RA synoviocytes can modulate the apoptotic process, resulting in accelerated and receded cell apoptosis, respectively, to perpetuate the disease activity.