Interestingly, PLIN5 deficiency was also implicated in the progression of atherosclerosis, as was shown in double knockout mice (ApoE−/−Plin5−/−) that developed more severe atherogenesis (with elevated TG, TC, and LDL-C levels, and reduced HDL-C contents) and accelerated inflammation, apoptosis, lipid accumulation, and OS. This evidence concerns the gene PLIN5 and atherosclerosis.