The most important ones include the upregulation of checkpoint receptor ligands, which results in the reduction of the number of tumor infiltrating lymphocytes (TIL), the production of soluble immunosuppressive factors (IL-10, TGF-beta), the downregulation of elements responsible for antigen presentation, and tumor infiltration by suppressor immune cells (regulatory T cells, Treg) [8]. This evidence concerns the gene IL10 and neoplasm.