From the analysis of RNA-sequencing data produced in our laboratory (GEO: GSE117609) [24], we detected both the circular and linear VAMP3 isoforms in human primary myoblasts, embryonal rhabdomyosarcoma (ERMS) RD cells and alveolar rhabdomyosarcoma (ARMS) RH4 cells. The gene discussed is VAMP3; the disease is rhabdomyosarcoma.