Magrassi et al. also reported the chromosomal 9 gain at the 9q22.1 region that was identified as the co-amplification of SHC-transforming protein 3 (SHC3) and sphingosine-1-phosphate receptor 3 (S1PR3, also called EDG3) in 60% of ependymomas [93]. The gene discussed is SHC3; the disease is ependymoma.