On the other hand, in urine, the transcripts ubiquitin conjugating enzyme E2 C (UBE2C) and serine protease inhibitor B1 (SERPINB1) arose as novel potential liquid biopsy biomarkers and the combination of these two transcripts provided an AUC value of 0.812 for the diagnosis of CCA. The gene discussed is UBE2C; the disease is cholangiocarcinoma.