Additionally, the presence of AnnexinV/EpCAM/ASGPR1+ tumor-associated microparticles (TAMPs) in the serum of patients with CCA or liver cancer (CCA and HCC) allowed their diagnosis, when compared with patients with liver cirrhosis (AUC of 0.630 and 0.700, respectively) although it did not differentiate between the two main types of primary liver cancer [104]. This evidence concerns the gene ANXA5 and cholangiocarcinoma.