More recently, levels of bile-derived circulating miR-30d-5p and miR-92a-3p were found upregulated in patients with CCA, when compared with patients with benign biliary disease (AUC of 0.730, and 0.652, respectively), although superiority over CA19-9 and CEA was not confirmed [48]. Here, CEACAM5 is linked to cholangiocarcinoma.