EGFR and neoplasm: Additionally, IGF2BP1 loss enhanced the levels of HGF, which is produced by stromal fibroblasts and contributes to epithelial cell proliferation and invasive growth of CRC cells by interaction with β-catenin signaling, and conferred resistance to EGFR inhibitors in colon tumor-initiating cells in fibroblasts in vitro, and increased fibroblast cell growth [34,35,36,37], indicating a potentially tumor-suppressive role of IGF2BP1 via modulating HGF in fibroblasts.