According to another study, black raspberry BRB anthocyanins could downregulate the expression of DNMT3A, DNMT3B, and p-STAT3 in CRC, resulting in the demethylation of the SFRP2 gene promoter and increasing the expression of SFRP2 at both the mRNA and protein levels. The gene discussed is SFRP2; the disease is colorectal carcinoma.